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Once a substance passes through the outer layers of skin, it passes into the lymph and local vascular blood vessel system and soon after into the bloodstream. While the exact mechanisms of skin transfer are yet to be completely understood, three routes of penetration have been hypothesized:.
Some of the most convincing stories of substances passing into the body via the skin come from governmental agencies actively studying and monitoring dermal absorption through their chemical safety divisions.
A report published by the World Health Organization takes a very clear position on skin permeability:. While the skin does act as a barrier, it is not a complete barrier. Many chemicals do penetrate the skin, either intentionally or unintentionally, and cutaneous metabolism does occur. Because of its large surface area, the skin may be a major route of entry into the body in some exposure situations. While government agencies such as those above work to stop the transfer of chemicals through the skin, transdermal drug delivery methods seek to take advantage of it.
Transdermal patches are produced as delivery systems for nicotine, hormones, pain killers, and others. These methods are coveted for their clear advantages over oral medications, as outlined by Stanley Scheindlin, pharmaceutical chemist, in the journal Molecular Interventions :. Patients often forget to take their medicine, and even the most faithfully compliant get tired of swallowing pills, especially if they must take several each day. Additionally, bypassing the gastrointestinal GI tract would obviate the GI irritation that frequently occurs and avoid partial first-pass inactivation by the liver.
While transdermal drugs are well known in the medical community, the difference with magnesium oil topical treatments is, of course, the fact that magnesium is an essential mineral to the human body, in a natural form. Thus, use of topical magnesium oil products brings all the advantages of transdermal applications, but none of the disadvantages of introducing foreign substances into the body.
Transdermal magnesium is a needed substance. Humans have been using the skin as a direct pathway into the body for centuries, and only recently have we begun to understand the science behind it.
Many people are familiar with the healing properties of saunas, used quite often for detox and general well-being. Ancient treatments in fact involved a variety of transdermal therapies ranging from mineral baths, to herbal compresses, to mud packs, to steam and sweat lodges.
These topical remedies were not limited to one culture, but were a part of many of the documented societies spread throughout the world.
More recent examples of topical and transdermal therapies can be found from the 18 th through the early 20 th century and eventually led to the technological advancements seen today. Throughout Europe, the skin as a gateway for medical therapy became increasingly popular in the late 18 th century.
In an age where open wounds often led to infection, topical remedies were favored over risky surgeries. For instance, soaking in sulfurous mineral baths became a widespread treatment for gout, which might otherwise have meant amputation.
Early editions of the United States Pharmacoepia USP contained several plasters, pastes applied with a cloth binding cover, which are precursors to current transdermal patches. Permeation is increased both with time magnesium chloride is left on the skin, as well as the concentration of the magnesium chloride solution, with increases in absorption seen up to 60 minutes after application. Key findings: Transdermally applied magnesium cream significantly increased magnesium levels in participants.
This pilot study set out to determine whether magnesium in a cream could be absorbed through the skin to increase magnesium status. While the placebo groups baseline levels did not differ, those with the magnesium cream saw a clinically relevant increase in both serum and urinary levels of magnesium.
Even though participant applied relatively low levels of magnesium 56 mg daily the magnesium cream showed a significant increase in magnesium levels. Skip to main content. Evidence of Transdermal Magnesium Absorption. In vitro transdermal delivery of magnesium. Key finding: Absorption through the skin started with immediate effect This in-vitro clinical trial carried out by the University of Cardiff proved that elemental magnesium could be delivered to the cells of the body through a transdermal delivery through the skin.
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